Best Medicine Cast & Episode Guide

Best Medicine Cast & Episode Guide

FOX · US

Latest New Episode: Love Is a Battlefield · S2 E7 — 10 November 2026

Next New Episode: Back to the Suture · S2 E8 — 17 November 2026 on FOX

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Best Medicine

Latest Best Medicine Episode

Upcoming Best Medicine Episodes

Back to the Suture · S2 E8

17 November 2026 · 8:00 PM EST · FOX · New

“Back to the Suture” places Dr. Martin in a race against incomplete medical information. He learns that his predecessor, the beloved Dr. Reese, identified a patient’s brain tumor shortly before his death, but the patient’s identity remains unknown. With Louisa’s help, Martin must work out who received that diagnosis and find them in time to provide the care they need. Set within the coastal community of Port Wenn, the Season 2 episode connects a serious medical problem with the lingering impact of Dr. Reese’s work.

The central problem begins with Dr. Reese’s final professional judgment. Because the diagnosis was made moments before he died and was not clearly linked to a named patient, Martin has to reconstruct the circumstances around it. The search gives the episode a focused medical mystery while keeping the stakes tied to one patient’s need for urgent attention.

About Best Medicine

Best Medicine is a FOX medical comedy-drama set in the fictional coastal village of Port Wenn. The series follows Martin, a physician whose demanding work brings him into contact with unusual medical cases, complicated personal relationships and the closely connected residents of the community.

How the Series Works

The series combines village-based medical storytelling with character-driven comedy. Martin investigates patients’ symptoms and navigates difficult diagnoses while his professional responsibilities intersect with local traditions, community tensions and the unpredictable behavior of the people around him. The format allows clinical mysteries and relationship complications to develop side by side.

The Port Wenn Community

Port Wenn is central to the series rather than serving merely as a backdrop. Martin’s work is shaped by the residents’ familiarity with one another, the town’s distinctive customs and the pressure of practicing medicine in a small community. Louisa is an important presence in Martin’s personal and professional world, while the memory of Dr. Reese reflects the lasting influence that local physicians can have on their patients and colleagues.

Series Cast & Characters

  • Josh Charles — Dr. Martin Best
  • Abigail Spencer — Louisa Gavin
  • Josh Segarra — Sheriff Mark Mylow
  • Annie Potts — Sarah Best
  • Cree — Elaine Denton
  • Stephen Spinella — Greg Garrison
  • Jason Veasey — George Brady

Best Medicine Episode Archive

1 previously aired episode in the archive.

Showing 1 of 1 new episode.

Love Is a Battlefield

10 November 2026 · Season 2, Episode 7

Best Medicine season 2, episode 7, “Love Is a Battlefield,” brings Martin into an unusual Port Wenn medical situation during a Revolutionary War reenactment.

Guest Cast (18)
  • Carter Shimp as Al Large
  • Didi Conn as Geneva Larson
  • John DiMaggio as Bert Large
  • Clea Lewis as Sally Mylow
  • Wendy Makkena as Susan Carlisle
  • Jack Cutmore-Scott as Parker
  • Buzz Roddy as Larry Jackson
  • Frank Wood as Franklin
  • Paul Bartholomew as Principal Halloway
  • Andy Riddle as Tim
  • Kathy Searle as Freda
  • John Edward Miller as Clark Flanagan
  • Aidan Hart as Johnny
  • Marita de Lara as Depressed Housewife Beatrice
  • Jon Okabayashi as Clyde
  • Sarah Dacey Charles as Nancy
  • Jay Klaitz as Ned
  • Michael Panes as Salty Breeze Fiddler